Robert W Nickells Selected Research

Glaucoma

10/2021	BCLXL gene therapy moderates neuropathology in the DBA/2J mouse model of inherited glaucoma.
4/2016	Retinal glial responses to optic nerve crush are attenuated in Bax-deficient mice and modulated by purinergic signaling pathways.
1/2016	Role of HDACs in optic nerve damage-induced nuclear atrophy of retinal ganglion cells.
11/2014	Tumor necrosis factor alpha has an early protective effect on retinal ganglion cells after optic nerve crush.
3/2013	Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.
3/2012	Silencing of Fem1cR3 gene expression in the DBA/2J mouse precedes retinal ganglion cell death and is associated with histone deacetylase activity.
3/2007	Dominant inheritance of retinal ganglion cell resistance to optic nerve crush in mice.
10/2006	Decrease of cone opsin mRNA in experimental ocular hypertension.
7/2005	Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage.
5/2004	Increased expression of iron-regulating genes in monkey and human glaucoma.

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Robert W Nickells Research Topics

Disease

11	Glaucoma 10/2021 - 07/2002
9	Ganglion Cysts (Ganglion) 11/2020 - 02/2004
7	Optic Nerve Injuries 11/2020 - 07/2005
4	Neoplasms (Cancer) 01/2016 - 09/2002
3	Mitochondrial Diseases (Mitochondrial Disease) 05/2021 - 02/2004
3	Atrophy 01/2018 - 09/2014
3	Optic Nerve Diseases (Optic Neuropathy) 04/2016 - 03/2013
2	Ocular Hypertension (Glaucoma, Suspect) 04/2007 - 10/2006
2	Retinoblastoma (Glioblastoma, Retinal) 10/2003 - 09/2002
1	Choroidal Neovascularization 08/2017
1	Wounds and Injuries (Trauma) 01/2016
1	Neuroinflammatory Diseases 12/2015
1	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2007
1	Hypercalcemia (Milk Alkali Syndrome) 09/2002
1	Abscess 07/2002
1	Blister (Bulla) 07/2002

Drug/Important Bio-Agent (IBA)

5	Histones (Histone)IBA 11/2020 - 03/2013
5	Retinaldehyde (Retinal)IBA 08/2017 - 05/2004
4	HeterochromatinIBA 11/2020 - 03/2013
4	Proteins (Proteins, Gene)FDA Link 11/2014 - 05/2004
3	Messenger RNA (mRNA)IBA 03/2007 - 05/2004
2	bcl-2-Associated X Protein (bcl 2 Associated X Protein)IBA 10/2021 - 07/2005
2	RGFP966IBA 11/2020 - 01/2018
2	Carisoprodol (Soma)FDA LinkGeneric 04/2016 - 10/2006
2	Calcitriol (Calcijex)FDA LinkGeneric 10/2003 - 09/2002
2	Vitamin D FDA LinkGeneric 10/2003 - 09/2002
1	arginyl- 2,'6'- dimethyltyrosyl- lysyl- phenylalaninamideIBA 05/2021
1	StaurosporineIBA 05/2021
1	ThrombospondinsIBA 08/2017
1	pigment epithelium-derived factorIBA 08/2017
1	RNA (Ribonucleic Acid)IBA 01/2017
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2016
1	Complement System Proteins (Complement)IBA 12/2015
1	CytokinesIBA 11/2014
1	NeurotoxinsIBA 11/2014
1	histone deacetylase 3IBA 09/2014
1	Pharmaceutical PreparationsIBA 03/2013
1	Protein Kinase InhibitorsIBA 03/2013
1	tozasertibIBA 03/2013
1	AntigensIBA 01/2013
1	trichostatin A (A 300)IBA 03/2012
1	Histone Deacetylase InhibitorsIBA 03/2012
1	theasinensin AIBA 03/2012
1	LigandsIBA 07/2010
1	Apoptosis Regulatory ProteinsIBA 07/2010
1	Peptides (Polypeptides)IBA 07/2010
1	Glutamic Acid (Glutamate)FDA Link 04/2007
1	Rod OpsinsIBA 10/2006
1	Cone OpsinsIBA 10/2006
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 07/2005
1	IronIBA 05/2004
1	Ceruloplasmin (Ferroxidase)IBA 05/2004
1	CopperIBA 05/2004
1	Ferritins (Ferritin)IBA 05/2004
1	AntioxidantsIBA 05/2004
1	Transferrin (beta 2 Transferrin)IBA 05/2004
1	CaspasesIBA 02/2004
1	Bromodeoxyuridine (BrdU)IBA 10/2003
1	ParaffinIBA 10/2003
1	Antineoplastic Agents (Antineoplastics)IBA 10/2003
1	TransferasesIBA 10/2003
1	CalciumIBA 09/2002
1	Calcitriol Receptors (Calcitriol Receptor)IBA 09/2002
1	beta Subunit Luteinizing HormoneIBA 09/2002
1	Ergocalciferols (Ergocalciferol)FDA LinkGeneric 09/2002
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 09/2002
1	Mitomycin (Mitomycin-C)FDA LinkGeneric 07/2002

Therapy/Procedure

3	Therapeutics 10/2021 - 02/2004
2	Trabeculectomy (Trabeculoplasty) 04/2007 - 10/2006
1	Axotomy 01/2016
1	Laser Therapy (Surgery, Laser) 10/2006
1	Post and Core Technique (Technique, Post) 10/2006
1	Light Coagulation 05/2004
1	Lasers (Laser) 05/2004
1	Ligation 10/2003
1	Filtering Surgery 07/2002
1	Aftercare (After-Treatment) 07/2002